After reporting at Washington, D.C. in November 1863, the unit was sent to fight in the Western Theater of the American Civil War.

The regiment fought at Okolona, Brices Cross Roads, and Nashville, while one company was in action at Byram's Ford in Missouri.

Thereafter, the regiment was assigned to occupation duties in Louisiana and Texas before being mustered out in May 1866.

Attached to District of Columbus, 6th Division, 16th Army Corps, Dept.

1st Brigade, 1st Cavalry Division, 16th Corps, to June, 1864.

1st Brigade, 2nd Cavalry Division, District of West Tennessee, to November, 1864.

Cavalry Brigade, District of Baton Rouge, La., Dept.

A detachment moved to Little Rock, Ark., and on expedition against Price, Nonconah Creek, November 20 (Co. "F").

Hollow Tree Gap, Franklin and West Harpeth River December 17.

Moved to Vicksburg, Miss., thence to New Orleans, La., February 8-March 9, and to Baton Rouge, La., March 20.

Company "A" duty at Shreveport until December 15, then at Marshall, Texas, until April, 1866.

Company "C" at Monroe until December 15, 1865, then at Jefferson, Texas, until April, 1866.

Regiment lost during service 15 Enlisted men killed and mortally wounded and 3 Officers and 109 Enlisted men by disease.