It spent its entire existence west of the Mississippi River in the Trans-Mississippi Department.

In fall 1862, the unit was assigned to the 3rd Brigade of the Texas infantry division known as Walker's Greyhounds and fought at Milliken's Bend in June 1863.

The unit was in action at Mansfield, Pleasant Hill, and Jenkins' Ferry in 1864.

The last units in the Trans-Mississippi surrendered in June 1865, but the 19th Regiment had already disbanded before that date.

This article about a specific military unit of the American Civil War is a stub.