[3][4] Diego (Adrían Suar) and Richard (Juan Minujín) are two renowned cardiovascular surgeons who own an important specialist hospital located in Puerto Madero, Buenos Aires.

Diego is married to Emilia (Julieta Díaz), a weather forecaster, with whom he has a 14-year-old son called Lucas (Tomás Wicz) and an organized family life.

Richard is in a ten-year relationship with Betina (Carla Peterson), a fashion designer; they have no children and a more unstructured life.

In Lucas' birthday party, Betina tells Emilia that she thinks Richard is cheating on her and becomes emotionally unstable the following days.

[6] La Prensa's Isabel Croce highlighted Julieta Díaz's performance and described the film as "a good comedy starring an attractive foursome".

[7] La Capital called Alfredo Casero's role "noteworthy" and wrote "it is a movie with risky events and direct, crude language, but fails to exceed the occurrence of Un novio para mi mujer.

[8] La Voz del Interior considered "one of the successes of 2+2 is the choice of the cast" and that it has "very funny moments, risky and very well done erotic scenes, tense situations that give nuance to the story.

"[10] Julio Nakamurakare of the Buenos Aires Herald called 2+2 "so predictable and narrow-minded as to negate what's been previously proclaimed out loud as a war cry.