2,4,5-Trihydroxyamphetamine (THA) is a neurotoxin and a metabolite of MDMA.

It comes from the ring-hydroxylation of 3,4-methylenedioxyamphetamine (MDA).

In one paper, it was shown to reduce hippocampal tryptophan hydroxylase activity by 54% after short-term treatment.

[1] In another study, it was shown to significantly reduce striatal tyrosine hydroxylase activity.

This neurotoxin article is a stub.