[1][2][3] In addition, it produces widespread generalized toxicity at higher doses.

[1] Its selective serotonergic neurotoxicity is due to its high affinity for the serotonin transporter (SERT).

[2] Because of its SERT affinity, 5,6-DHT has activity as a serotonin reuptake inhibitor.

[1] The compound can be used in scientific research to lesion the brain serotonergic system in animals.

[1][2][3] It has a number of limitations and disadvantages relative to 5,7-DHT however, which have made 5,7-DHT a more preferred serotonergic neurotoxin in scientific research.