2-Decanone can be found in meats, dairy products and eggs, fruits (banana, mountain papaya, berries), vegetables (potato, mushroom, endive, soya bean, chayote, kumazase), and grains such as maize, rice, and oats.

It also is present in fish, some nuts, honey, ginger, garlic, vanilla, hop oil, mate, brandy, tea, and coffee.

[4] 2-Decanone was also found at varying percentages in the essential oils of plants within the Ruta genus, including R. montana and R.

[7] 2-Decanone has been found to possess strong fumigant activity against the maize weevil.

[7] 2-Decanone can be synthesized by reacting 2-decanol with permanganic acid and copper sulfate in DCM.