The opener at Yankee Stadium on a cool night was a pitchers' duel between Freddy García and Denny Neagle, and the game was scoreless through four innings.

Alex Rodriguez led off the sixth inning with a home run high off the left field foul pole's screen to give the M's another.

The Yankees outhit the Mariners by one, but could not score off García (6+2⁄3 innings) and relievers José Paniagua, Arthur Rhodes, and Kazuhiro Sasaki; Seattle took the opener with a 2–0 shutout.

Hernández pitched eight innings and gave up just one run, a Stan Javier single in the third that scored Mike Cameron, who had walked with two outs and stole second, after nearly being picked off at first.

Posada was caught diving back to third for the second out on a safety squeeze; José Vizcaíno then doubled to left center to score Sojo from first to make it 4–1 Yankees.

Closer Mariano Rivera pitched a scoreless ninth: Olerud sliced a ground-rule double to lead off, but three ground balls ended the game; the series was tied at 1–1 and headed to Seattle.

In the bottom of the eighth, Rodriguez singled and stole second, but Martínez struck out, and closer Mariano Rivera relieved Jeff Nelson.

Chuck Knoblauch hit an RBI single up the middle off of Brett Tomko, who then walked Jeter (after a lengthy at-bat) to load the bases.

Lefthander Robert Ramsay relieved Tomko and allowed a two-run single to right by Justice and a sacrifice fly to left by Williams to make it 8–2.

[12][13] In one of the most dominant pitching performances in postseason history, Yankees starter Roger Clemens struck out 15 batters in a complete game one-hit shutout of the Mariners.

[14] Clemens carried a no-hitter into the seventh inning when Al Martin lined a leadoff double off first baseman Tino Martinez's glove for the Mariners' only hit of the game.

After Rickey Henderson was caught looking, Yankee starter Denny Neagle walked three straight to load the bases in the bottom of the first; Mike Cameron scored on a sacrifice fly to right from John Olerud, then Jay Buhner struck out.

The Yankees responded in the fourth when Tino Martinez doubled to right-center, Jorge Posada singled to left, and Paul O'Neill walked to load the bases with no outs.

With the New York Mets clinching the National League pennant the night before with a 7-0 victory over the St. Louis Cardinals, the Yankees now had an opportunity to guarantee the first Subway Series since 1956.

The Mariners again struck first in Game 6, taking a 2–0 lead in the first when Yankees starter Orlando Hernández walked Al Martin, then gave up back-to-back doubles to Alex Rodriguez and Edgar Martínez.

The Yankees responded in the bottom of the inning when they loaded the bases before Jorge Posada hit a double off John Halama that scored David Justice and Bernie Williams.

[19] 2000 ALCS (4–2): New York Yankees over Seattle Mariners On September 26, 2000, NBC declined to renew its broadcast agreement with Major League Baseball.

Major League Baseball coverage would eventually return to NBC Sports in 2022 via a deal with their streaming service Peacock to broadcast games on Sunday afternoons.