2000 Arizona Cardinals season

[3] Arizona's minus-233 point differential is the worst in team history.

Following the most lopsided of those eight road losses, 48–7 at Dallas in week eight, coach Vince Tobin was fired, ending his tenure in the desert after 4½ seasons with a 29–44 record.

Defensive coordinator Dave McGinnis was named interim coach, and he held the job through the end of the 2003 season.

The Cardinals suffered through their poorest season since the 1970 AFL–NFL merger, eclipsing the 4–12 marks of 1991, 1992, 1995 and 1997.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve On December 18, Dave McGinnis was named as the 38th head coach in franchise history.

He had been interim coach since October 23, when Vince Tobin was fired.