The 2000 season was the Detroit Lions' 71st in the National Football League (NFL).

After a wildcard playoff appearance with an 8–8 record in 1999, the Lions improved to 9–7 in 2000, but missed the playoffs thanks to a Christmas Eve home loss to the 4–11 Chicago Bears, where they blew a 10-point lead in the second quarter.

Nonetheless, this was the Lions' sixth winning season in 10 years, capping one of the best decades in the franchise's history.

Head coach Bobby Ross resigned after the ninth game of the season and was replaced by Gary Moeller.

Head coaches Offensive coaches Defensive coaches Special teams coaches Strength and conditioning [2] Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve [3]