The 2000 Tirreno–Adriatico was the 35th edition of the Tirreno–Adriatico cycle race and was held from 8 March to 15 March 2000.

The race started in Sorrento and finished in San Benedetto del Tronto.

[2] The race was won by Abraham Olano of the ONCE team.

Twenty-two teams participated in the race:[3]