Ascoli has good rail connections to the Adriatic coast and the city of San Benedetto del Tronto, by highway to Porto d'Ascoli and by the Italian National Road 4 Salaria to Rome.

[8] Discovered artifacts in the city such as sling bullets show that the siege included at least four Roman legions as well as Gallic and Spanish auxiliaries.

After nearly two centuries as part of the Lombard Duchy of Spoleto (593–789), Ascoli was ruled by the Franks through their vicars, but ultimately it was the bishops that gained influence and power over the city.

In 1189 a free republican municipality was established but internal strife led dramatically to the demise of civic values and freedom and to unfortunate ventures against neighboring enemies.

This unstable situation opened the way to foreign dictatorships, like those of Galeotto I Malatesta (14th century), initially recruited as a mercenary (condottiero) in the war against Fermo, and Francesco Sforza.

Recent industrialization has brought to Ascoli several Italian and multinational companies (YKK, Manuli, Pfizer, Barilla) but the bulk of the economy is made up of small and medium-sized enterprises and by those providing professional services to the area.

The parade is followed by a tournament, called Quintana, in which six knights, each competing for one of the six neighborhoods in the city, ride the course one after the other trying to hit an effigy of an Arab warrior.