[2][3] The Yankees then attempted to win a fourth consecutive World Series title, but lost a close seventh game on the road to the Arizona Diamondbacks.

The Yankees took a 1–0 lead on a Chuck Knoblauch single that scored Jorge Posada in the second off Aaron Sele, then increased it to 3–0 on a Paul O'Neill two-run home run in the fourth.

[9][10] Thursday, October 18, 2001 at Safeco Field in Seattle, Washington New York took a 2–0 lead in the second against Freddy García on a Scott Brosius double that scored Tino Martinez and Jorge Posada, who singled and walked, respectively.

After David Bell flied out, Ichiro Suzuki was intentionally walked to load the bases and Mark McLemore cleared them with a triple.

In the ninth, Witasick allowed a one-out home run to Jay Buhner, then a triple to Al Martin, who scored on Olerud's single.

[13][14] Sunday, October 21, 2001 at Yankee Stadium (I) in Bronx, New York Starting pitchers Paul Abbott and Roger Clemens both lasted only five innings, but Game 4 remained scoreless until the top of the eighth.

Mariano Rivera retired the side in order in the ninth, and Mariners closer Kazuhiro Sasaki got the first out, then allowed an infield single by Scott Brosius.

[15][16] Through the seventh, each team had just one hit: John Olerud's leadoff single in the fourth off Clemens for the Mariners, and Tino Martinez's ground-rule double off Norm Charlton in the sixth for the Yankees.

[15][16] Monday, October 22, 2001 at Yankee Stadium (I) in Bronx, New York In the bottom of the third inning, an error by Mariner third baseman David Bell allowed Scott Brosius to reach base.

Joel Piñeiro relieved him and struck out Brosius, but then threw a wild pitch to Soriano to let all three runners move up.

In the bottom of the eighth, Tino Martinez hit a three-run home run off José Paniagua, and Mariano Rivera pitched a scoreless ninth, retiring Mike Cameron for the final out of the series, as the Yankees cruised to a 12–3 win and advanced to a fourth consecutive World Series.