The 2001 IGA U.S. Indoor Championships was a women's tennis tournament played on indoor hard courts in Oklahoma City, Oklahoma in the United States and was part of Tier III of the 2001 WTA Tour.

It was the 16th edition of the tournament ran from February 18 through February 25, 2001.

First-seeded Monica Seles won her second consecutive singles title at the event.

Monica Seles defeated Jennifer Capriati 6–3, 5–7, 6–2 Amanda Coetzer / Lori McNeil defeated Janet Lee / Wynne Prakusya 6–3, 2–6, 6–0