The 2001 Internazionali Femminili di Palermo was a women's tennis tournament played on outdoor clay courts in Palermo, Italy that was part of the Tier V category of the 2001 WTA Tour.

It was the 14th edition of the Internazionali Femminili di Palermo and took place from 9 July until 15 July 2001.

Ninth-seeded Anabel Medina Garrigues won the singles title and earned $16,000 first-prize money.

[1] Anabel Medina Garrigues defeated Cristina Torrens Valero, 6–4, 6–4 Tathiana Garbin / Janette Husárová defeated María José Martínez Sánchez / Anabel Medina Garrigues, 4–6, 6–2, 6–4