The Cardinals went 93–69 during the season and finished tied for first in the National League Central with the Houston Astros.

Because the Cardinals and Astros were best two teams in the National League, both from the Central, and both finished five games ahead of the third-place Chicago Cubs, the Astros were awarded the NL Central champion and the number 1 seed in the playoffs due to winning the season series 9–7, and the Cardinals were awarded the wild-card.

[1] In the playoffs the Cardinals lost to the eventual World Champion Arizona Diamondbacks 3 games to 2 in the NLDS.

[9] On September 3, Bud Smith became the ninth Cardinal and eighteenth rookie to hurl a no-hitter.

Infielders Other batters Coaches Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg.