Conference play began with a win over the Iowa State Cyclones in Ames, Iowa on October 4, and ended with an upset loss to the Kansas State Wildcats in the 2003 Big 12 Championship Game on December 6.

Following the season, Tommie Harris was selected 14th overall in the 2004 NFL draft, along with Teddy Lehman in the 2nd round, and Derrick Strait in the 3rd.

Roster [2] Antonio Perkins became the first Division I-A player in history to have three returns for a score in one game while also breaking the NCAA single-game punt return yardage record.

[5] [6] The 2004 NFL draft was held on April 24–25, 2004 at The Theater at Madison Square Garden in New York City.

The following Oklahoma players were either selected or signed as undrafted free agents following the draft.