They were led by third-year head coach Jerry Kill and played their home games at McAndrew Stadium in Carbondale, Illinois.
The Salukis finished the season with a 10–2 record overall and a 6–1 record in conference play, making them conference co-champions with Northern Iowa.
The team received an at-large bid to the Division I-AA playoffs, where they lost to Delaware in the first round.
9 in The Sports Network's postseason ranking of FCS teams.
This college football 2000s season article is a stub.