Anagennisi Germasogeias won their 1st title.
Fourteen teams participated in the 2005–06 Cypriot Fourth Division.
The team with the most points at the end of the season crowned champions.
Teams promoted to 2005–06 Cypriot Third Division Teams relegated from 2004–05 Cypriot Third Division 1AEK/Achilleas Ayiou Theraponta withdrew from the 2005–06 Cypriot Fourth Division.
Teams promoted from regional leagues Teams relegated to regional leagues