The 2010–11 Cypriot Fourth Division was the 26th season of the Cypriot fourth-level football league.
Ormideia FC won their 1st title.
Fourteen teams participated in the 2010–11 Cypriot Fourth Division.
The team with the most points at the end of the season were crowned champions.
The first three teams were promoted to the 2011–12 Cypriot Third Division and the last three teams were relegated to regional leagues.