Artmedia reached the group stages of the UEFA Champions League after wins over Kairat Almaty, Celtic and Partizan Belgrade.

On 23 August 2005 they clinched a place in the group stages after overcoming Serbian powerhouse Partizan Belgrade 4–3 on penalties after a 0–0 aggregate scoreline, thus becoming the second Slovak club after 1.

Eventually, they finished third in the group, parachuting them into the UEFA Cup, but not before missing a late chance to score a goal in the return fixture against Porto that would have sent them to the round of 16 at Rangers' expense.

Artmedia lost the home leg of their UEFA Cup round of 32 tie with Levski Sofia 1–0 and were knocked out of the tournament after an away defeat of 2–0.

[1] Several players left the club, including Ján Ďurica (to FC Saturn Ramenskoe), Balázs Borbély (to Kaiserslautern) and Blažej Vaščák (to Treviso).