The 2005–06 Macedonian First League was the 14th season of the Macedonian First Football League, the highest football league of Macedonia.
The first matches of the season were played on 5 August 2005 and the last on 21 May 2006.
Rabotnichki defended their championship title, having won their second title in a row.
The first 22 matchdays will consist of a regular double round-robin schedule.
The league standings at this point will then be used to determine the games for the last 11 matchdays.