Lija Athletic and St. Patrick were the teams which were relegated from the 2004–05 Maltese Premier League.
Tarxien Rainbows and St.Andrews were the promoted teams.
St. Georges were the champions and Marsa were the runners-up.
This was two straight relegations for Lija while St. Andrews were sent back down having just been promoted.
The Maltese First Division 2005–06 was made up of these teams: