The Crimson Tide received a bid to the 2006 Cotton Bowl Classic against Texas Tech, where they defeated the Red Raiders on a last-second field goal by Jamie Christensen.

[6] The Blue Raiders responded on the next drive with a 14-yard Marks touchdown pass to Nick McAfee to cut the Alabama lead to 9–7 at halftime.

[6] The Crimson Tide scored on their opening drive of the third quarter when Brodie Croyle threw a 13-yard touchdown pass to Tyrone Prothro.

[7] Alabama retook the lead in the third quarter after Tim Castille scored on a two-yard touchdown run, and led 23–21 after a failed Christensen extra point.

[9] The final points of the game came early in the fourth quarter on the second two-yard Castille touchdown run of the evening to give the Crimson Tide the 30–21 victory.

[15][17] Three plays later Kenneth Darby scored on a 22-yard touchdown run to give the Crimson Tide a 30–7 lead entering the fourth quarter.

[15][16] With the second-string playing in the fourth, John Parker Wilson threw a 36-yard touchdown pass to Brown for the final Alabama points of the afternoon.

[19][20] After holding the Crimson Tide to a three-and-out, the Razorbacks' Kyle Dickerson blocked a Jeremy Schatz punt that was recovered by John Aaron Rees at the Alabama eleven-yard line.

[27] Following the Hetland field goal, Alabama again scored on a one-play drive when Croyle connected with Keith Brown for a 65-yard touchdown reception to give the Crimson Tide a 24–3 halftime lead.

Early in the fourth quarter, he broke both his tibia and fibula after landing awkwardly in a failed attempt to make a touchdown reception on a fourth-and-five play.

[30][31] After Tim Castille failed to gain a first down on a fourth-and-one on the Rebels' six-yard line, both teams traded turnovers on successive drives.

[33][34] After trading fumbles on two of the three opening possessions, Jamie Christensen missed a 50-yard field goal attempt late in the first quarter for Alabama.

After DeMeco Ryans recovered a fumbled punt by Lucas Taylor at the 50-yard line, Christensen connected on a 33-yard field goal six plays later to give the Crimson Tide a 3–0 lead.

[34][36] In Tennessee's final possession, DeMeco Ryans intercepted a pass by Erik Ainge as time expired, sealing the Crimson Tide's victory.

[37][38] Sources:[39] In what was the final regular season, non-conference game, Alabama defeated the Utah State Aggies 35–3 on homecoming in Tuscaloosa.

[41] The Aggies scored their only points of the game on their opening drive of the second half when Justin Hamblin connected on a 24-yard field goal.

[41] With the reserves playing in the fourth quarter, Alabama scored their final points when John Parker Wilson connected with Glen Coffee for a nine-yard touchdown reception and a 35–3 Crimson Tide victory.

[40][41] Sources:[42] Against long-time rival Mississippi State, the Alabama defense had its first shutout of the season and the offense did not have a touchdown in their 17–0 victory over the Bulldogs.

[42][43] After a scoreless first quarter, Jamie Christensen scored the first points of the game with his 38-yard field goal to give the Crimson Tide a 3–0 halftime lead.

[44] On the ensuing Mississippi State drive, Michael Henig threw an interception to Rudy Griffin that was returned 17 yards for an Alabama touchdown and a 17–0 victory.

[44][45] Sources:[46] With College GameDay in town, in what was the first loss of the season for the Crimson Tide, the LSU Tigers defeated Alabama 16–13 in overtime.

[51] Auburn responded later in the second quarter with a five-yard Cox touchdown pass to Cole Bennett to give the Tigers a 28–7 lead at halftime.

[52] Sources:[53] On December 4 officials from the Cotton Bowl announced their 2006 contest would feature the Crimson Tide competing against the Texas Tech Red Raiders of the Big 12 Conference.

Alabama's Jamie Christensen missed a 39-yard field goal and the second blocked by Chris Hudler and recovered by Dwayne Slay.

[56] The Red Raiders' Trlica had a 37-yard field goal blocked by Mark Anderson as time expired to give Alabama the 7–3 halftime lead.

[53] Texas Tech then tied the game up at 10–10 late in the fourth quarter after Cody Hodges threw a 12-yard touchdown pass to Jarrett Hicks.

[56] The Crimson Tide responded on the following drive with Christensen kicking the game-winning field goal from 45-yards out as time expired to give Alabama the 13–10 victory.

After a prolonged investigation, in June 2009 the NCAA ruled all athletes that received improper benefits related to the textbook distribution system were deemed ineligible.

[63] As such, as part of the penalties imposed on the football program, all victories which those included in the inquiry participated, were officially vacated from the all-time record.