First baseman Albert Pujols won the MVP Award this year, batting .330, with 41 home runs and 117 RBIs.

The final regular season game at Busch Memorial Stadium took place on October 2, a 7-5 victory over the Cincinnati Reds.

Rookie Chris Duncan hit the final regular season home run at that version of Busch Stadium.

Down to their last out and strike and facing elimination in game 5 of the 2005 National League Championship Series, David Eckstein hit a single in the hole on the left side off of the Astros' Brad Lidge to bring the tying run to the plate.

Albert Pujols followed with a 412-foot home run onto the train tracks behind left field (had the game been played with the roof open, the drive would have exited Minute Maid Park, as it first hit off the glass wall which forms part of the roof),[citation needed] to put the Cardinals ahead 5–4.

Houston was then shut down in the bottom of the 9th by the Cardinals' closer Jason Isringhausen to preserve the win, guaranteeing at least one more game at old Busch Stadium.