The season began on May 17, 2006 with a match between defending premiers Glen Mills Bulls and the Philadelphia Fight, played at Jack Pearson Stadium.

The same venue hosted the Grand Final between the Connecticut Wildcats and Glen Mills Bulls on August 19, 2006 in front of a crowd of 2,500.

[1] Three expansion teams, the Jacksonville Axemen, the New Haven Warriors, and the Boston Braves joined the AMNRL for the 2006 season.

After the regular season concluded, six of these teams qualified for the first week of the playoff series, with the Connecticut Wildcats victors in the Grand Final, securing their second championship title.

The season culminated on August 19, 2006, with the 4th placed Connecticut Wildcats defeating the minor premiers Glen Mills Bulls 36-28 in the Grand Final Championship Match in front of 2,500 people at Jack Pearson Stadium in Concordville, Pennsylvania.