Coached by Brian Smith and Jason Taylor and captained by Nathan Cayless, they competed in the NRL's 2006 Telstra Premiership.

[1] The Parramatta Eels began the 2006 season with the knowledge that their coach Brian Smith, would not be there next season, after being asked to step down by the management of the Parramatta Eels rugby league club in what turned out to be a direct trade with the Newcastle Knights club for their coach, Michael Hagan.

However, Smith resigned officially on 15 May 2006, after an extremely poor start to the season, which left the Parramatta side running 14th and second-last.

[2] Assistant coach and former Parramatta player, Jason Taylor, took over as caretaker manager for the rest of the year and led a Parramatta resurgence in the second-half of the season to eventually reach eighth position by season's end including a nine-game winning streak.

The current playing squad and coaching staff of the Parramatta Eels for the 2006 NRL season as of 21 September 2006.