Coached by Graham Murray and captained by Travis Norton, they competed in the NRL's 2006 Telstra Premiership.
Coming off the back of their maiden Grand Final appearance, the Cowboys were strong premiership favourites heading into the 2006 season.
They looked like they would be living up to those expectations, with a six-game winning streak to start the season.
1 The Melbourne Storm were later stripped of this minor premiership due to gross salary cap breaches.
2 The New Zealand Warriors were deducted 4 competition points due to gross salary cap breaches.