The 2006 NCAA Division I lacrosse tournament was the 36th annual tournament hosted by the National Collegiate Athletic Association to determine the team champion of men's college lacrosse among its Division I programs, held at the end of the 2006 NCAA Division I men's lacrosse season.

[3] The Cavaliers, led by Matt Ward and Ben Rubeor, completed a perfect 17-0 record and won their fourth NCAA championship and sixth overall national lacrosse title.

The Minutemen became the second unseeded team to make the NCAA final (Towson State also accomplished this in 1991).

[4] Sixteen NCAA Division I college men's lacrosse teams met after having played their way through a regular season, and for some, a conference tournament.

Denver made their debut appearance in the Division I men's lacrosse tournament.