The 2006 Southeastern Louisiana Lions football team represented Southeastern Louisiana University as a member of the Southland Conference during the 2006 NCAA Division I FCS football season.

Led by second-year head coach Dennis Roland, the Lions compiled an overall record of 2–9 with a mark of 1–5 in conference play, placing last in the Southland.

Southeastern Louisiana played home games at Strawberry Stadium in Hammond, Louisiana.

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