The 2006 Texas Southern Tigers football team represented Texas Southern University as a member of the West Division of the Southwestern Athletic Conference (SWAC) during the 2006 NCAA Division I FCS football season.
Led by third-year head coach Steve Wilson, the Tigers finished the season with an overall record of 3–8 and a mark of 3–6 in conference play, tying for third place in the SWAC's West Division.
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