[2] Athletic director Mal Moore announced defensive coordinator Joe Kines as interim head coach for the Independence Bowl,[2] against Oklahoma State, which the Tide lost 34–31, finishing with a 6–7 record.

[3] The most notable departures were Kenneth Darby and Le'Ron McClain on offense, and Dominic Lee, Jeremy Clark, Juwan Simpson, Terrence Jones, Jeffrey Dukes, and Ramzee Robinson on defense.

The entire starting offensive line returned, anchored by freshman All-American Andre Smith, along with reinforcements by the top four tight ends from the 2006 depth chart.

[10][11] In accordance with conference rules, Alabama faced all five Western Division opponents: Arkansas, Auburn, LSU, Mississippi State, and Ole Miss.

[14] [13] On January 3, 2007, Alabama announced that Nick Saban was hired from the Miami Dolphins to serve as the program's 27th head coach.

[28] Sources:[29] For the 19th consecutive time, stretching back to the 1984 season, Alabama defeated the Vanderbilt Commodores to open conference play.

[32][33] Leigh Tiffin hit a 20-yard field goal later in the quarter as did the Commodores' Bryant Hahnfeldt from 33 yards to make the score 10–3 at the end of the first.

[30] Sources:[35] In what was considered their first true test of the season, Alabama built an early 21-point lead but had to mount a come-from-behind drive in the final two minutes of the game in order to capture a 41–38 victory against the Arkansas Razorbacks.

[35][37] The Razorbacks closed the gap to 21–10 at the half after Casey Dick threw a 40-yard touchdown pass to Crosby Tuck and Alex Tejada converted a 22-yard field goal.

[35] Alabama extended their lead to 31–10 in the third quarter after a 24-yard Leigh Tiffin field goal and a two-yard Wilson touchdown pass to Nick Walker.

In the fourth Darren McFadden scored on runs of one and five yards on consecutive drives, and Peyton Hillis had a seven-yard touchdown reception to give the Razorbacks a 38–31 lead with 8:08 remaining in the game.

Hall set a new Crimson Tide record for career receiving yardage previously held by Ozzie Newsome with 2,070 yards.

Sources:[38] A week after upsetting Arkansas and entering both the AP and Coaches' Polls, Alabama was defeated in overtime by the Georgia Bulldogs 26–23.

[40] Brandon Coutu and Leigh Tiffin each added a field goal in the second quarter for their respective teams to give the Bulldogs a lead 10–3 at halftime.

Florida State scored on their first play of the second half when Xavier Lee connected with De'Cody Fagg for a seven-yard touchdown reception.

[43] Alabama scored their first points of the evening late in the fourth quarter when John Parker Wilson threw a seven-yard touchdown pass to D. J.

It was the first time the teams had met since 1974, and it was the first meeting since Birmingham, Alabama native Bobby Bowden took over as head coach of the Seminoles.

[47] On the ensuing Cougar drive, Wallace Gilberry sacked Houston quarterback Blake Joseph for a safety and a 9–0 Alabama lead.

[46][47] For his eleven tackle, two sack performance, Wallace Gilberry was named SEC Defensive Line Player of the Week.

Terry Grant scored on a three-yard run and Tiffin kicked the game-winning field goal from 24 yards with 5:14 remaining in the game.

[56] Tiffin added three more field goals to bring his total to four on the day in the second half, and Terry Grant had an eight-yard touchdown run in the fourth to give Alabama the 41–17 victory.

Sources:[63][64] Coming a week after a tough loss to LSU, the Mississippi State Bulldogs defeated Alabama for the second consecutive season, this time by a score of 17–12.

[71][72] Auburn took a 10–0 lead in the first quarter with Ben Tate scoring on a three-yard touchdown run and Wes Byrum connecting on a 37-yard field goal.

[71] However, the Crimson Tide were unable to recover the onside kick on the ensuing kickoff and Auburn was able to run out the clock to preserve the 17–10 victory.

[80][81] As part of the A-Day celebrations on April 12, 2008, the 2007 team captains Antoine Caldwell, Rashad Johnson and Darren Mustin were honored at the Walk of Fame ceremony at the base of Denny Chimes.

Four players were named to the Coaches' All-SEC First Team, including Andre Smith, Wallace Gilberry, Simeon Castille and Rashad Johnson.

[94] As a result of this discovery, Antoine Caldwell, Marlon Davis, Glen Coffee, Marquis Johnson and Chris Rogers were suspended from the team prior to the Tennessee game on October 20.

[95] After a prolonged investigation, in June 2009 the NCAA ruled all athletes that received improper benefits related to the textbook distribution system were deemed ineligible.

[96] As such, as part of the penalties imposed on the football program, all victories which those included in the inquiry participated, were officially vacated from the all-time record.

[98] John Parker Wilson with the Atlanta Falcons, Bobby Greenwood with the Kansas City Chiefs, Marlon Davis with the Cleveland Browns, Nick Walker with the Minnesota Vikings and Travis McCall with the Buffalo Bills each signed as undrafted free agents.