It was a best-of-seven series, with the West Division champion and top-seeded Arizona Diamondbacks facing the divisional rival wild card winner Colorado Rockies.

The Rockies won the opportunity to play the American League champion Boston Red Sox in the 2007 World Series, where they were swept 4-0.

In the seventh, reliever Juan Cruz issued a leadoff walk to Yorvit Torrealba, who moved to second on a wild pitch and then to third on Francis's sacrifice bunt.

After Taveras struck out, Diamondbacks first baseman Conor Jackson's fielding error on Matsui's ground ball allowed Torrealba to score to make it 5-1 Rockies.

In the bottom of the inning, Francis allowed a leadoff double to Chris Snyder and hit Justin Upton with a pitch, but the Diamondbacks were taken out of a potential rally when a disputed interference call resulted in a double-play groundout for Augie Ojeda.

Though they loaded the bases on Jeff Cirillo's bunt single and Chris Young's walk off of reliever Matt Herges, Jeremy Affeldt got Drew to fly out to right to end the inning.

In the bottom of the ninth, Colorado closer Manny Corpas blew the save when he hit Young with a pitch with one out and subsequently allowed a single to Stephen Drew.

The Rockies won their first pennant in franchise history with a 6–4 win in Game 4, completing a sweep of the number one seed Arizona Diamondbacks.

Kazuo Matsui's single scored Smith before NLCS MVP Matt Holliday's three-run home run to deep center put the Rockies up 6-1.

Corpas allowed a one-out double to Young in the ninth, but got Drew to pop out to second and Eric Byrnes, the center of controversy before Game 3, to hit a check-swing roller to Troy Tulowitzki, who fired to Todd Helton at first to retire the diving Byrnes and send Colorado to the 2007 World Series against the Boston Red Sox.

Colorado was also the first team to have a 7–0 start to a postseason since the 1976 Cincinnati Reds finished the playoffs 7–0 sweeping both the LCS and World Series.

In subsequent years, this became more common as MLB expanded to more postseason teams over time and the rule where you could not play a division opponent in the LDS was also eliminated.

Due to a scheduling quirk and the ALCS between Boston and Cleveland going a full seven games, the Rockies' eight-day layoff between the NLCS and World Series was the longest in MLB postseason history.