Carlos Mármol would take the loss in relief of Zambrano, allowing a lead off home run to Mark Reynolds in the seventh, then, one out later, walking Chris Snyder, who moved to third on Augie Ojeda's double and scored on a sacrifice fly by Conor Jackson.

In the seventh, Davis walked two with two outs before being relieved by Juan Cruz, who allowed a two-run double to pinch hitter Daryle Ward that made it 8–4 Arizona.

Michael Wuertz in relief walked Young to load the bases, then struck out Drew before Eric Byrnes hit into a forceout at second that scored Miguel Montero.

The Cubs cut Arizona's lead to 3–1 in the bottom of the inning off of Liván Hernández when Mark DeRosa hit a leadoff single, moved to third on Jacque Jones's double, and scored on Jason Kendall's groundout.

Solo home runs by Byrnes in the sixth off of Carlos Marmol and Drew in the ninth off of Kerry Wood capped the scoring as the Diamondbacks' 5–1 win completed a sweep of the Cubs, who hit into four double plays.

Matt Holliday homered off of Tom Gordon in the eighth inning to provide insurance after consecutive home runs by Aaron Rowand and Pat Burrell led off the Phillies' half of the fifth.

In the seventh, Shane Victorino singled with one out off of Ryan Speier, advanced to third on a stolen base attempt and Torrealba's throwing error, and scored on Rollins's groundout.

Philadelphia loaded the bases in the eighth inning, but Manny Corpas earned a four-out save in stranding all three runners, sealing the Rockies' 10–5 victory.

Rockies starter Ubaldo Jimenez pitched six shutout innings, but Shane Victorino's home run to right in the top of the seventh tied the game and ended his night.

After being released mid-season by the Red Sox, J. C. Romero became one of the most reliable bullpen arms for the Phillies down the stretch by not giving up a single run in 15+2⁄3 innings pitched in September.