For the first time in Philippine history, Antonio Trillanes was elected as a senator while currently detained for mutiny and rebellion charges.

On March 11, 2007, the Old COMELEC Building in Intramuros, Manila was burned by a blazing fire ruining several ballot boxes and pending election protests.

The Genuine Opposition considered the fire as political act which ended in burning of several election protests and contested ballot boxes.

Jojo then filed for a motion for reconsideration which was eventually rejected on May 11, 2007, but COMELEC did not remove his name from the Official List of Senatorial Candidates and ruled on May 12, 2007, that all votes with only the name "CAYETANO" will be stray votes (discarded) and therefore not counted to either the candidates until Supreme Court resolved the matter.

TEAM (Together Everyone Achieves More) Unity was the administration-backed coalition composed mostly of supporters and erstwhile critics of then-President Gloria Macapagal Arroyo.

TEAM Unity sought to take several Senate seats in order to ensure the passage of President Arroyo's legislative programs and also to protect her from any impeachment attempts by the political opposition after the midterm elections.

On February 15, 2007, the group changed its name again to Genuine Opposition after a meeting with Senate President Manny Villar in his office in Las Piñas.

Iglesia ni Cristo, a known religion being courted for its block voting, endorsed 6 TEAM Unity (TU) members (Ralph Recto, Joker Arroyo, Ed Angara, Mike Defensor, Juan Miguel "Migz" Zubiri, and Tito Sotto), Five Genuine Opposition (GO) senatorial bets (Loren Legarda, Manny Villar, Panfilo Lacson, Chiz Escudero, and Noynoy Aquino III), with one independent (Kiko Pangilinan).

[3] Bayan Muna endorsed Legarda, Escudero, Cayetano, Pimentel, Roco, Coseteng, and Villar from GO; Arroyo and Recto of TU; and independent Pangilinan.

Prospero Pichay Jr., Manny Villar, Mike Defensor, and Loren Legarda had been very visible in TV ads.

Francis Pangilinan preferred to run as an independent and decided not to participate in sorties and campaign of the Genuine Opposition, even though he was initially drafted as a guest candidate.

Teresa Aquino-Oreta had raised different reactions in her TV ad campaign asking the people's forgiveness being the “dancing queen” during the impeachment of deposed President Joseph Estrada.

Some candidates like Francis Escudero, Vicente Magsaysay, Francis Pangilinan, Joker Arroyo, Antonio Trillanes and Koko Pimentel made use of the internet by joining networks sites like Friendster; making or updating Wikipedia entries, establishing blogs and websites and airing the commercials on YouTube.

Five incumbents successfully defended their seats: Edgardo Angara and Joker Arroyo for TEAM Unity, Panfilo Lacson and Manny Villar from GO, and Francis Pangilinan of the Liberal Party.

GO's Benigno Aquino III, Alan Peter Cayetano, Francis Escudero, Antonio Trillanes, and TEAM Unity's Migz Zubiri are the neophyte senators.

[16] Pimentel sued former president Gloria Macapagal Arroyo, COMELEC chairman Benjamin Abalos, Maguinadanao elections supervisor Lintang Bedol and others for electoral sabotage on August 17, 2011, at the Department of Justice (DOJ).