Luis Ayala, Alex Escobar, Cristian Guzmán, Nick Johnson, Michael O'Connor and John Patterson were expected to return from season-ending injuries.
After losing four starters (Liván Hernández, Tony Armas, Ramón Ortiz and Pedro Astacio) from the prior year, the Nationals invited an extraordinary 36 pitchers to spring training.
On December 18, 2006, the Nationals traded José Vidro and cash to the Seattle Mariners for Emiliano Fruto and Chris Snelling.
[4] The Nationals held their 2007 spring training in Viera, Florida, with home games played at Space Coast Stadium.
They invited Danny Ardoin to spring training, but he did not make the team; they traded him to the Houston Astros for minor-leaguer Wade Robinson on March 26, 2007.
[5] On Opening Day, the Nationals lost their starting shortstop (Cristian Guzmán, hamstring) and center fielder (Nook Logan) for five weeks.
"[7] They pressed journeymen Mike Bacsik, Micah Bowie (a relief pitcher) and Jason Simontacchi, along with rookie reliever Levale Speigner into the starting rotation, amidst predictions that the 2007 Nationals might equal the 1962 Mets' record of futility, 120 losses in one season.
[23] On August 7, 2007, in a game against the San Francisco Giants at AT&T Park, Nationals pitcher Mike Bacsik gave up career home run number 756 to Barry Bonds, who broke a 33-year-old record previously held by Hank Aaron.