The 2008 Bank of America 500 was a NASCAR Sprint Cup Series stock car race held on October 11, 2008 at Lowe's Motor Speedway in Concord, North Carolina.

The 334-lap, 501 miles (806 km) race was televised on ABC.

The race's television broadcast began at 7 pm ET, and the Performance Racing Network along with Sirius Satellite Radio had radio coverage starting at the same time.

Jeff Burton earned his 21st and final Cup Series victory with this race.

Because of rain, qualifying was canceled for the eighth time this season, and so the cars lined up by rulebook.