The 2008 Masters Series Hamburg was a men's tennis tournament played on outdoor clay courts.

It took place at the Rothenbaum Tennis Center in Hamburg, Germany, from 10 May through 18 May 2008.

1 and defending champion Roger Federer, Monte Carlo winner and 2007 Hamburg runner-up Rafael Nadal, and Australian Open and Rome winner Novak Djokovic.

Other top seeds competing were Miami champion Nikolay Davydenko, Valencia Open winner David Ferrer, James Blake, Richard Gasquet and Tomáš Berdych.

Rafael Nadal defeated Roger Federer, 7–5, 6–7(3–7), 6–3 Daniel Nestor / Nenad Zimonjić defeated Bob Bryan / Mike Bryan, 6–4, 5–7, [10–8]