The 2008 Madrid Masters (also known as the Mutua Madrileña Masters Madrid for sponsorship reasons) was a tennis tournament played on indoor hard courts.

Fourth-seeded Andy Murray won the singles title.

1, Beijing Olympics singles gold medalist, French Open and Wimbledon, Monte Carlo, Hamburg, Toronto Masters champion Rafael Nadal, ATP No.

2, US Open titlist, Olympic doubles gold medalist, Madrid defending finalist Roger Federer, and Australian Open, Indian Wells, Rome Masters winner Novak Djokovic.

Other top seeds were US Open runner-up, Cincinnati Masters titlist Andy Murray, Miami Masters, Pörtschach, Warsaw winner Nikolay Davydenko, David Ferrer, David Nalbandian and Andy Roddick.