Fox televised the contest, with Joe Buck and Tim McCarver in the booth for the game broadcast, joined at the bottom of the 2nd inning by President Barack Obama.

[5] On April 22, 2009, All-Star balloting began on MLB.com with eight position players (excluding pitchers and designated hitters) from each of the 30 teams being nominated for fans to vote.

National League manager Charlie Manuel of the Philadelphia Phillies selected Tony La Russa of the host St. Louis Cardinals and Joe Torre of the Los Angeles Dodgers as his coaches.

Stan Musial, a former player for the host St. Louis Cardinals and a member of the Baseball Hall of Fame, gave the baseball for the ceremonial first pitch to the President of the United States Barack Obama, who threw it to the hometown Cardinals' first baseman and leading All-Star vote-getter, Albert Pujols, while wearing a White Sox jacket.

An instrumental version was played through stadium speakers during the opening ceremonies, a move criticized by Canadian player Justin Morneau.

With one out, Mark Teixeira hit a groundball that was misplayed by first baseman Albert Pujols allowing Jeter to score the game's first run.

Singles by David Wright, Shane Victorino and Yadier Molina, plus a ground rule double by Prince Fielder, all with two outs, gave the NL the lead.

The American League tied the score at three in the fifth on a two-out double by Joe Mauer off Chad Billingsley, and retook the lead when Adam Jones drove in Curtis Granderson, who tripled off Heath Bell, on a sacrifice fly in the eighth.

American League pitchers at one point retired 18 straight batters (and 22 of the final 24) on just 48 pitches before Joe Nathan walked Adrián González with two outs in the eighth.

Carl Crawford went 1-for-3 but made a great defensive catch in the seventh inning to rob Brad Hawpe of a home run.

[16] This was the seventh straight win for the American League since the All-Star game had first been used to determine home-field advantage for the World Series.

MLB International televised the game in English outside of the U.S., with announcers Gary Thorne (play-by-play) and Rick Sutcliffe (color commentator).