The 2010–11 season was Fotbal Club CFR 1907 Cluj's 7th consecutive season in the Liga I and 103rd year in existence as a football club.

In addition to the domestic league, CFR Cluj participated in that season's editions of the Cupa României, the Supercupa României and the UEFA Champions League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Source: [1] Source: Competitions As the previous season's Liga I and Cupa României winners, CFR Cluj played against league runners-up Unirea Urziceni in the 2010 Supercupa României.