The 2010–11 Macedonian Football Cup was the 19th season of Macedonia's football knockout competition.
Teteks were the defending champions, having won their first title.
The 2010–11 champions were Metalurg who won their first title.
The draw was held on 7 July 2010 in Skopje.
The first legs took place on 15 September 2010 and the second legs took place on 28, 29 September, 9 and 10 October 2010.