On May 25, 2010, the Lightning announced Hockey Hall of Fame player and former Detroit Red Wings executive Steve Yzerman as their new general manager.
Stamkos led the League with 19 points, scoring nine goals and assisting on ten, and was tied for the second-best plus-minus rating at +9.
He underwent surgery on November 15 and was placed on the injured reserve list, expected to miss four-to-five weeks.
On January 1, 2011, Nate Thompson scored just 19 seconds into the overtime period to give the Lightning a 2–1 home win over the New York Islanders.
Note: GP = Games played; TOI = Time on ice (minutes); W = Wins; L = Losses; OT = Overtime losses; GA = Goals against; GAA= Goals against average; SA= Shots against; SV= Saves; Sv% = Save percentage; SO= Shutouts †Denotes player spent time with another team before joining Lightning.