Source: RSSSF[1] Source: RSSSF[2] Defensor Sporting eliminated on goal difference 3–4.

Nacional eliminated by finishing in 3rd place in their group.

Peñarol defeated by Santos on points 1–4.

River Plate eliminated on away goals.

This section covers Uruguay's senior team matches from the end of the 2010 FIFA World Cup until the end of the 2011 Copa América.