The winner qualified for the 2011 Copa Libertadores, the 2011 Recopa Sudamericana, and the 2011 Suruga Bank Championship.

Starting with this edition, each country gained an additional berth, with the exception of Argentina and Brazil.

Boca Juniors and River Plate were no longer invited to the competition without merit.

The draw for this tournament took place on April 28 in Luque at the CONMEBOL Conventions Center.

Note: The bracket was adjusted according to the rules of the tournament so that the two Brazilian teams would face each other in the semifinals.

LDU Quito, as the defending champion, entered directly into this stage and carries seed O8.

In the finals, if the finalists are tied on points after the culmination of the second leg, the winner is the team who scored the most goals.