The 2010–11 NCAA Division I men's basketball season began on November 8, 2010, with the preliminary games of the 2010 Coaches vs. Cancer Classic, and ended with the 2011 NCAA Division I men's basketball tournament's championship game on April 4, 2011, at Reliant Stadium in Houston, Texas.

A number of early-season tournaments marked the beginning of the college basketball season.

[101] Antwan Carter of Longwood was named Independent Player of the Year.

Source for additional stats categories A "major upset" is defined as a win by a team seeded seven or more spots below its defeated opponent.

Played at Madison Square Garden in New York City The fourth College Basketball Invitational (CBI) Tournament was held beginning March 15 and ended with a best-of-three final, ending April 1.