The Tigers, led by second-year head coach Gene Chizik were members of the Western Division of the Southeastern Conference and played their home games at Jordan–Hare Stadium.

The Tigers completed a 12–0 regular season record and defeated South Carolina in the 2010 SEC Championship Game.

In the second year of the Chizik era of Auburn football, offensive coordinator Gus Malzahn continued use of his hurry-up no-huddle schemes.

However, the Tiger defense was notably improved in the second halves of its 2010 games, allowing an average of only 3.7 fourth-quarter points and shutting out five opponents (Mississippi State, South Carolina, Louisiana-Monroe, Georgia and Alabama) in the final period.

Also, true freshman running back Michael Dyer ran 14 times for 95 yards in an impressive college debut.

The Auburn defense looked much improved from their week one game with Arkansas State and kept the Bulldogs in check most of the night.

Early it looked as if Clemson was going to blow Auburn out of its own building as the visiting Tigers stormed out to a 17–0 lead.

Clemson missed the second FG attempt and Auburn had survived another heart stopping game, 27–24.

Cam Newton bounced back after a horrible first half and finished the night 7/14 for 203 yards with 2 TD's and 2 INT's.

Auburn scored 31 points on their first five possessions of the game en route to an easy victory over the Warhawks of Louisiana–Monroe.

The Tigers went ahead 7–0 on their second play from scrimmage on a 50-yard touchdown run by sophomore tailback Onterrio McCalebb and the ensuing PAT by Wes Byrum.

Unlike the previous four games, Newton had no rushing attempts except for a 4-yard loss on a quarterback sack, but he completed 14 of 19 passes for 249 yards.

Senior kicker Wes Byrum connected on a 24-yard field goal as time expired to cap a 37–34 victory over the homestanding Kentucky Wildcats.

With the victory, the Tigers improved their record to 6–0 overall, and 3–0 in the Southeastern Conference, where they moved to a half-game behind Western Division leader LSU.

Arkansas and Auburn combined for 1036 yards of total offense and 108 points in the highest scoring non-overtime game between two conference opponents in SEC history as the Tigers defeated the Razorbacks.

Wes Byrum kicked two field goals in the period, including a 26-yarder on the first half's final play to give the Tigers a 27–21 lead.

Onterrio McCalebb scored a touchdown on a 70-yard run with 5:05 remaining in the game to give Auburn a 24–17 victory over LSU.

The win also ended a three-week streak that saw the #1 ranked team in either the wire service polls or the BCS standings lose on the road.

Auburn totaled 624 yards on offense in defeating the FCS Mocs for the 21st time in as many meetings between the two schools in a series that was first contested in 1925.

The Bulldogs led 21–7 at the end of the first quarter thanks to three touchdown passes by redshirt freshman quarterback Aaron Murray, but Auburn fought back to tie the game at 21–21 on an 18-yard touchdown pass from Cam Newton to tight end Philip Lutzenkirchen with 51 seconds remaining in the first half.

Auburn's lead was short-lived, as the Bulldogs tied the game at 28–28 six plays later on seven-yard run by Washaun Ealey.

Down 0–24 in the second quarter, Auburn rallied to defeat Alabama 28–27 in the 75th edition of the Iron Bowl at Bryant–Denny Stadium.

The Crimson Tide went ahead 7–0 with 11:34 to go in the first quarter on a 9-yard touchdown rush by Mark Ingram II, the 2009 Heisman Trophy winner.

Auburn was forced to punt the ball back to Alabama after three plays, and the host team took possession at their own 19-yard line.

Two plays later, senior quarterback Greg McElroy completed a 68-yard touchdown pass to wide receiver Julio Jones, and the Crimson Tide led 14–0 less than seven minutes into the game.

The Tigers' offense finally got on track, and Cam Newton completed a 36-yard touchdown pass to Emory Blake, cutting the Tide's lead to 24–7 at halftime.

As it had been through the previous twelve games of the season, the Auburn offense was led by quarterback Cam Newton, who threw for a career-best 335 yards.

Heisman Trophy winner Cam Newton completed a 35-yard touchdown pass to former quarterback Kodi Burns and a successful PAT kick by Wes Byrum with 12:00 remaining in the first half.

The Tigers cut the deficit to two points when Mike Blanc tackled James in the end zone for a safety with 3:26 remaining in the half, making the score 11–9.

Auburn held onto its eight-point lead until Oregon's LaMichael James caught a two-yard touchdown pass from Darron Thomas with 2:33 remaining in the fourth quarter and another successful two-point conversion tied the score at 19–19.