The Seminoles were led by fourth-year head coach Jimbo Fisher and played their home games at Bobby Bowden Field at Doak Campbell Stadium in Tallahassee, Florida.

Since the National Championship, numerous players have gone on to win a Super Bowl, including Bryan Stork, Tre' Jackson, Ronald Darby, Timmy Jernigan and Cameron Erving.

Former Alabama assistant coach, Jeremy Pruitt, joined the Florida State staff as the new defensive coordinator, replacing Mark Stoops.

[2][3] Prior to the start of the season, wide receiver Greg Dent was suspended indefinitely following an arrest and subsequent charge of sexual battery.

[6] During the offseason, tight end Nick O'Leary (grandson of Jack Nicklaus) was involved in a motorcycle accident but recovered before the start of the season.

At the start of fall practice, freshman tight end Jeremy Kerr suffered a knee cartilage tear leaving him sidelined for an undetermined amount of time.

[10] FSU led the league with six preseason All-ACC selections in Tre' Jackson, Bryan Stork, and James Wilder, Jr. on offense along with Timmy Jernigan, Christian Jones, and Lamarcus Joyner on defense.

Florida State scored touchdowns on two consecutive drives[30] with two passes from quarterback Jameis Winston to Kenny Shaw and Rashad Greene to take a ten-point lead into the half.

Kicker Roberto Aguayo was also honored as the ACC Specialist of the Week after a game that saw him kick a career long field goal of 33 yards as well as make all eight extra-point attempts.

Florida State then scored three straight touchdowns courtesy of Kelvin Benjamin, James Wilder Jr., and Devonta Freeman to carry a thirty-three point lead into halftime.

[36] Florida State would then score the final fourteen points of the game with two touchdown runs from newly converted RB Karlos Williams.

[42] After stopping Florida State on their first offensive possession, Boston College took the early lead with a touchdown pass from BC quarterback Chase Rettig.

However, the Seminoles rattled off twenty-one unanswered points including a "Hail Mary" pass, with no time remaining, at the end of the second quarter to take a seven-point lead at the half.

[43] Boston College then began a promising drive, but P. J. Williams intercepted the ball and returned it for a touchdown to put the Noles up 48–27 late in the game.

However, Florida State would score another fourteen points in the second quarter courtesy of two five-yard touchdown runs from Devonta Freeman and Kelvin Benjamin.

The Seminoles opened up the second half with another scoring drive capping off with an eight-yard pass from Jameis Winston to tight end Nick O'Leary to extend the lead to twenty eight.

[51] Florida State continued to score in the fourth with another twenty-one point quarter that consisted of touchdowns from Kelvin Benjamin and Karlos Williams along with backup QB Jacob Coker.

In 2012, Florida State was victorious with a 49–37 comeback win over the Tigers in Tallahassee en route to an Atlantic Division title and an ACC Championship.

[54] Florida State last traveled to Death Valley in 2011, a game the Seminoles lost 35–30,[55] furthering their win drought in Clemson, a place they have not won at since 2001.

Under the lights (and with the attendance of College GameDay), Florida State stunned the third-ranked Clemson Tigers, 51–14,[56] becoming the first team in history to score 50 points at Memorial Stadium.

[57] Clemson scored their first points of the game near the end of the first quarter with a touchdown pass from Tajh Boyd to Sammy Watkins to cut the lead back down to ten.

[59] With the win, Florida State became bowl eligible for the thirty-second consecutive year, the longest active streak in college football.

[77] The Seminoles scored the first points on the opening drive of the game when Devonta Freeman ran the ball into the endzone to give Florida State an early seven-point lead.

[91] Following their opening drive, Terrence Smith intercepted Tanner Price's pass and set up Devonta Freeman to score on a one-yard touchdown run.

[112] In the final quarter, Florida State scored two more touchdowns, a rush from Karlos Williams and a pass from backup Sean Maguire to Ryan Green.

[121] The offense was more productive in the second quarter, scoring their first touchdown of the game when Jameis Winston completed a 45-yd pass to Kelvin Benjamin to put them up by ten.

[123] Florida State extended their lead when Devonta Freeman rushed 11 yards for a touchdown[123] to give the Seminoles a twenty-seven point advantage.

Florida scored their first points of the game in the fourth quarter courtesy of a 5-yd pass from third-string quarterback Skyler Mornhinweg to Hunter Joyer.

[124] The final score of the game would come from Roberto Aguayo who kicked 28-yd field goal[124] to give the Seminoles a thirty-point win over the rival Gators.

The Seminoles won the ACC title, defeating the Blue Devils, 45-7, earning a spot to play in the BCS National Championship Game as the only undefeated team left in the country.