In 2008, Bia began racing in the American Firestone Indy Lights Series for defending championship-winning team Sam Schmidt Motorsports under the name Ana Beatriz.

Bia placed fifth in the Firestone Freedom 100 at Indianapolis Motor Speedway on 23 May 2008, the highest finishing position by a female driver in that race.

She was forced to miss the Milwaukee Mile race due to a lack of funding caused by a hard crash in the Freedom 100 the prior week.

Bia's official Portuguese language site revealed on 23 February 2010 that she will drive a third car for Dreyer & Reinbold Racing in the São Paulo Indy 300 in March 2010.

[9] Bia qualified for the 2010 Indianapolis 500 on the outside of row seven with a four–lap average of 224.243 MPH and finished in 21st position after retiring on the final lap of the race, as she was involved in an accident with Ryan Hunter-Reay and teammate Mike Conway.

Bia became a fan favorite in the event as she went from her starting position of 11th to 1st, overtaking experienced drivers such as Tony Kanaan, Felipe Massa and Rubens Barrichello in the process.

She ended 4th in the final standings despite scoring the same number of points as the winner, Lucas di Grassi (it was a four-way tie).

[13] In June 2020, De Figuereido's husband and father-in-law were charged with embezzling BR$9 million from the Lagos Rio Health Institute, around a sixth of which was alleged to have funded her career in Stock Car Brasil.