She started the year off by reaching the semi-finals of the Australian Open, where she lost to eventual champion Serena Williams, 7–6(4), 7–6(1).
She earned her spot in the tournament by winning the Aegon Classic, defeating Maria Sharapova, 7–5, 6–1 in the final.
Li narrowly missed qualifying for the 2010 WTA Tour Championships at Doha, Qatar after she was overtaken by Victoria Azarenka in the Points race.
Rezaï won her most prestigious title of her career yet, at the Mutua Madrileña Madrid Open- a Premier Mandatory Tournament where she scored wins over former world no.
Still dealing with the consequences from her drug ban, Wickmayer made a great start to the season, winning the ASB Classic without dropping a set, beating top seed Flavia Pennetta, 6–3 6–2 in the final.
But nonetheless, she proved worthy of a seeding spot, reaching the fourth round of the Grand Slam, eventually losing to finalist, and fellow Belgian, Justine Henin.
12 in April, but subsequently began falling down the rankings when she was unable to defend her semi-final points at the US Open, losing to 31st seed Kaia Kanepi 0–6, 7–6(2), 6–1.
She was also able to win her first two career titles at the Monterrey Open over Daniela Hantuchová, 1–6, 6–1, 6–0, and in the İstanbul Cup, where she defeated fellow Russian Elena Vesnina 5–7, 7–5, 6–4 in the final, earning her a spot in the Tournament of Champions.
However, Ivanovic reached the semifinals at Internazionali BNL d'Italia and W&S Financial Group Masters and Women's Open (withdrawing due to a foot injury) to improve in the rankings after falling to as low as World No.
Ivanovic finally won her first tournament in two years in Generali Ladies Linz defeating Patty Schnyder 6–1, 6–2, in just 45 minutes.
Kleybanova made a breakthrough this year, winning her first two career titles, which earned her a spot in the tournament of champions.
Kleybanova had her most consistent results in the slams so far, reaching the third round of all the Slams except for the US Open where she was defeated by Sara Errani in the second round.Daniela Hantuchová[10] Hantuchová has had good results this year, reaching her first final in over 2 and a half years in the Monterrey open, but subsequently lost to Anastasia Pavlyuchenkova 1–6, 6–1, 6–0.
[12] The total prize money for the 2010 Commonwealth Bank Tournament of Champions is 600,000 United States dollars.