The 2010 Conference USA baseball tournament was the 2010 postseason college baseball championship of the NCAA Division I Conference USA, held at Cougar Field in Houston, Texas, from May 26–May 30, 2010.

Southern Miss won the tournament and received Conference USA's automatic bid to the 2010 NCAA Division I baseball tournament.

It consisted of six teams split into two three-team pods.

The team with the best record in each pod going advanced to a single-game final.

# - Received an at-large bid to the NCAA tournament.